Mobile Cloud Computing Architecture Model for Multi-Tasks Offloading

In modern era the cell phones has born through the significant technological advancements. But this resides a low multi tasks entity. Many people use mobile devices instead of PC’s. Cell phones has limited number of resources like limited storage, battery time and processing. The cloud computing offloading deals with these limitations. Cloud computing become more attractive as it reduce the cost and also time efficient. Business of all sizes can’t afford to purchase hardware and softwares but cloud computing provide these resources and executes multiple tasks and allows the user to access their data and provide other control in each level of cloud computing.  All of these techniques save smart phones properties or capabilities but it also becomes the reasons of communication cost between cloud and smart phone devices. The main advantage of cloud computing is to provide multiple properties at different prices. These applications has goal to attain versatile performance objective. In this research work, an architecture model for multi tasks offloading designed to overcome this problem. For this purpose CloudSim simulator use with the NetBeans and implement the MCOP algorithm. This algorithm solves the execution timing issue and enhances the mobile system performance. In this tasks are partitioning into two parts and then implemented on cloud site or locally. It reduces the time response and communication cost or tasks execution cost. Keywords: Mobile Cloud Computing, Mobile Computing Offloading, Smart Mobile Devices, Optimal Partitioning Algorithm

Comparison of efficacy and safety of zinc gluconate versus placebo for treatment of Primary Dysmenorrhea

Background & Objectives: Dysmenorrhea is a common gynecological complaint in women of reproductive age. Primary dysmenorrhea is defined as painful menstruation in the absence of any pelvic pathology and occurs in response to increased prostaglandin release from the ischemic endometrium. Conventional treatments include NSAIDs and oral contraceptive pills.  Zinc is an essential micronutrient with anti-inflammatory properties. We conducted this study to evaluate the efficacy and safety of zinc supplementation in treatment of primary dysmenorrhea in our target population as it presents as very common gynaecological issue in young adolescents females.   Methods: 100 participants with primary dysmenorrhea were enrolled in study from outpatient department via non-probability consecutive sampling. They were randomized into two groups. The intervention group (Group A) received zinc gluconate 50mg once daily and the control group (Group B) received placebo drug once daily, for 5 days before and 2 days after onset of menstruation. After three and six months of treatment severity of primary dysmenorrhea was assessed and compared in both groups using visual analogue scale for pain, along with side effect profile. Results: The treatment with Zinc gluconate reduced the mean pain score in females with primary dysmenorrhea after 3months with a further reduction after 6 months of treatment (P<0.001) as compared to placebo. Very few (4% after 3 months & 6% after 6 months) participants experienced the side effects of Zinc supplementation. Conclusion: zinc gluconate 50mg daily for 5 days before and 2 days after onset of menstruation can effectively treat the primary dysmenorrhea. The drug has very few side effects at this dose and duration of use. Key words: Primary dysmenorrhea, zinc gluconate, pain severity, visual analogue scale. &nbsp

Comparison of efficacy and safety of zinc gluconate versus placebo for treatment of Primary Dysmenorrhea

Background & Objectives: Dysmenorrhea is a common gynecological complaint in women of reproductive age. Primary dysmenorrhea is defined as painful menstruation in the absence of any pelvic pathology and occurs in response to increased prostaglandin release from the ischemic endometrium. Conventional treatments include NSAIDs and oral contraceptive pills.  Zinc is an essential micronutrient with anti-inflammatory properties. We conducted this study to evaluate the efficacy and safety of zinc supplementation in treatment of primary dysmenorrhea in our target population as it presents as very common gynaecological issue in young adolescents females.   Methods: 100 participants with primary dysmenorrhea were enrolled in study from outpatient department via non-probability consecutive sampling. They were randomized into two groups. The intervention group (Group A) received zinc gluconate 50mg once daily and the control group (Group B) received placebo drug once daily, for 5 days before and 2 days after onset of menstruation. After three and six months of treatment severity of primary dysmenorrhea was assessed and compared in both groups using visual analogue scale for pain, along with side effect profile. Results: The treatment with Zinc gluconate reduced the mean pain score in females with primary dysmenorrhea after 3months with a further reduction after 6 months of treatment (P<0.001) as compared to placebo. Very few (4% after 3 months & 6% after 6 months) participants experienced the side effects of Zinc supplementation. Conclusion: zinc gluconate 50mg daily for 5 days before and 2 days after onset of menstruation can effectively treat the primary dysmenorrhea. The drug has very few side effects at this dose and duration of use. Key words: Primary dysmenorrhea, zinc gluconate, pain severity, visual analogue scale. &nbsp

Relationship and Difference of Levels Between Schadenfreude, Social Media Addiction and Social Comparison Among Adults and Adolescents

This study aims to explore the relationship and difference in levels of Social Media Addiction, Social Comparison and Schadenfreude among adults and adolescents. The study followed a quantitative, correlational survey design. The research was conducted with a sample size of 500 participants (Males n= 252 & Females n=248) aged between 13 to 25 years (M= 17.54, SD= 3.32). A purposive convenient sampling technique was used. Findings from statistical analysis revealed that social media addiction and Social Comparison have positive moderate correlation. This study also found that there is no significant difference between adolescents and adults in Social Media Addiction and Social Comparison, but the difference is manifested in Schadenfreude between adolescents and adults. This study highlighted the importance of identity exploration, virtue education, empathy as well as raising awareness regarding behavioral addiction that can reduce the later on negative consequences

The Impact of Workplace Incivility on The Psychological Wellbeing of Employees Through Emotional Exhaustion

Workplace environment has received a lot attention from many authors for research purpose. The present study extends the scope of the workplace incivility literature by adding the dependent variable like psychological wellbeing, prohibitive voice behaviour, intention to leave. I have selected these research variables because of its importance however, the association of these variables with the workplace incivility as independent variable is the unique contribution of the study to the existing body of knowledge. All the dependent variables are also helpful in the career development of employees and make contribution to achieve organization goals. This research will help organizations to study how workplace incivility affects the behaviour of the employees, besides it helps organizations to consider the workplace incivility effects on the employees while making decisions in achieving organization goals. Another significant achievement of the study is the use of emotional exhaustion as a mediator. The mediation role of emotional Exhaustion between workplace incivility and dependent variables like psychological wellbeing, prohibitive voice behaviour and intention to leave reveals much truth through mediation analysis. The use of prohibitive voice behaviour as an independent variable is also uniqueness of this study, it will reveal a lot of facts how prohibitive voice behaviour effects the employees in the organization. This study also uses the mechanism of the Conservation of resource theory to explain and justify the impact of workplace incivility on prohibitive voice behaviour, psychological wellbeing of employees and intention to leave. Although various researchers use the COR theory this study the theory describes how employees have the negative feelings and out of their resources (Knowledge, skills, ability) when dealing with workplace incivility

Recombinant deoxyribonucleoside kinase from Drosophila melanogaster can improve gemcitabine based combined gene/chemotherapy for targeting cancer cells

A recombinant deoxyribonucleoside kinase from Drosophila melanogaster with a deletion of the last 20 amino acid residues (named DmdNKΔC20) was hypothesized as a potential therapeutic tool for gene therapy due to its broad substrate specificity and better catalytic efficiency towards nucleosides and nucleoside analogs. This study was designed to evaluate the effect of DmdNKΔC20 for sensitizing human cancer cell lines towards gemcitabine and to further investigate its role in reversal of acquired drug resistance in gemcitabine-resistant cancer cell line. The DmdNKΔC20 gene was delivered to three different cancer cell lines, including breast, colon and liver cancer cells, using lipid-mediated transfection reagent. After transfection, gene expression of DmdNKΔC20 was confirmed by reverse transcription quantitative PCR (qRT-PCR) and the combined effect of DmdNKΔC20 and gemcitabine based cytotoxicity was observed by cell viability assay. We further evolved a gemcitabine-resistant breast cancer cell line (named MCF7-R) through directed evolution in the laboratory, which showed 375-fold more resistance compared to parental MCF7 cells. Upon transfection with DmdNKΔC20 gene, MCF7-R cells showed 83-fold higher sensitivity to gemcitabine compared to the control group of MCF7-R cells. Moreover, we observed 79% higher expression of p21 protein in transfected MCF7-R cells, which may indicate induction of apoptosis. Our findings highlight the importance and therapeutic potential of DmdNKΔC20 in combined gene/chemotherapy approach to target a wide range of cancers, particularly gemcitabine-resistant cancers

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Metabolic Engineered Biocatalyst: A Solution for PLA Based Problems

Polylactic acid (PLA) is a biodegradable thermoplastic polyester. In 2010, PLA became the second highest consumed bioplastic in the world due to its wide application. Conventionally, PLA is produced by direct condensation of lactic acid monomer and ring opening polymerization of lactide, resulting in lower molecular weight and lesser strength of polymer. Furthermore, conventional methods of PLA production require a catalyst which makes it inappropriate for biomedical applications. Newer method utilizes metabolic engineering of microorganism for direct production of PLA through fermentation which produces good quality and high molecular weight and yield as compared to conventional methods. PLA is used as decomposing packaging material, sheet casting, medical implants in the form of screw, plate, and rod pin, etc. The main focus of the review is to highlight the synthesis of PLA by various polymerization methods that mainly include metabolic engineering fermentation as well as salient biomedical applications of PLA

Iniencephaly

Iniencephaly is an uncommon form of neural tube defects which is characterized by retroflexion of the head and absence of neck as a consequence of defective closure of the vertebral body and arch. Multiple identified risk factors for its causation include environmental, genetic and drugs.&nbsp; We report a case of 38-year-old woman with prior history of still birth and abortions who presented at 35 weeks of gestation with lower abdominal pain and high blood pressure. Mother had consanguineous marriage. Her hypothyroidism was untreated in the first and second trimester. She delivered an iniencephalic baby girl via emergency c-section with multiple malformations at 38 weeks gestation secondary to fetal cardiac deceleration. Baby survived for less than 18 hours. In this case, proper antenatal care and follow up visits were needed along with postnatal genetic and pathological evaluation including assessment of risk factors. Appropriate management is important to prevent complications and recurrence in subsequent pregnancies.&nbsp; &nbsp